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Poisoning cause: MILD TO MODERATE Ethanol TOXICITY
Toxic dose : About 1 mL/kg (1 g/kg) of absolute ethanol. Per Olson guidleine:Acute ingestion of 150-200 mg/kg can produce mild intoxication,
Toxic serum or urine levels: Over 100 mg/dL
Management: Patients who appear mildly intoxicated may be simply managed with suppo... |
Poisoning cause: SEVERE Ethanol TOXICITY
Toxic dose : 5 to 6 g/kg in non-tolerant adults and 3 g/kg in children. Per Olson guidleine:Acute ingestion of 300-500 mg/kg can lead to severe intoxication. Chronic intoxication may occur with more than 100 mg/kg/day for 2 or more days.
Toxic serum or urine levels: Over 250... |
Poisoning cause: Sudden cessation of chronic ethanol
Management: Mild to Moderate AWS:
Benzodiazepines are central to treatment, administered either orally or intravenously.
Aim to control withdrawal symptoms and prevent seizures.
For mild AWS, a long-acting benzodiazepine like clorazepate may be used, starting with 30... |
Poisoning cause: MILD TO MODERATE Arsenic TOXICITY
Toxic dose : Acute ingestion of more than 0.05 mg/kg,Acute ingestion of more than 100 mg of inorganic arsenic is likely to cause significant toxicity
Toxic serum or urine levels: Over 100 mcg/L
Management: Fluid resuscitation should be initiated immediately, but care ... |
Poisoning cause: Subacute Arsenic toxicity
Toxic serum or urine levels: Toxic Urine Arsenic = Over 100 mcg/L
Clinical effect 1: Peripheral neuropathy
Clinical effect 2: Resembling guillain-barre syndrome |
Poisoning cause: SEVERE acute Arsenic TOXICITY
Toxic dose : Acute ingestion of more than 100-300 mg of inorganic arsenic is likely to cause significant toxicity.
Toxic serum or urine levels: Toxic Urine Arsenic = Over 100 mcg/L
Management: Aggressive life support measures should be instituted immediately. Anti-arrhythm... |
Poisoning cause: CHRONIC Arsenic TOXICITY
Toxic serum or urine levels: Toxic Urine Arsenic = Over 100 mcg/L
Clinical effect 1: Weakness
Clinical effect 2: Anorexia
Clinical effect 3: Hepatomegaly
Clinical effect 4: Jaundice
Clinical effect 5: Respiratory irritation
Clinical effect 6: Hyperpigmentation
Clinical effect 7... |
Poisoning cause: MILD TO MODERATE Phenobarbital TOXICITY
Toxic dose : Ingestion of 8 mg/kg phenobarbital generally causes some CNS depression in non-tolerant individuals.Toxicity is likely when the dose exceeds 5–10 times the hypnotic dose.
Toxic serum or urine levels: from 3 to 40 mcg/ml (lethargy and ataxia), from ... |
Poisoning cause: SEVERE Phenobarbital TOXICITY
Toxic dose : Ingestion of 8 mg/kg phenobarbital generally causes some CNS depression in non-tolerant individuals.Toxicity is likely when the dose exceeds 5–10 times the hypnotic dose.
Toxic serum or urine levels: from 3 to 40 mcg/ml (lethargy and ataxia), from 60 to 150 ... |
Poisoning cause: MILD TO MODERATE Valproic acid TOXICITY
Toxic dose : Over 50 mg/kg
Toxic serum or urine levels: Over 100 mcg/ml
Management: Symptomatic and supportive care in all patients. Monitor for progression of sedation. Repeat valproic acid levels every 4 to 6 hours and consider multidose activated charcoal if t... |
Poisoning cause: SEVERE Valproic acid TOXICITY
Toxic dose : Over 200 mg/kg
Toxic serum or urine levels: Serum levels exceeding 450 mg/L are associated with drowsiness or obtundation.
Levels greater than 850 mg/L are associated with coma, respiratory depression, and metabolic perturbations.
Management: Resuscitation, sy... |
Poisoning cause: MILD TO MODERATE Carbamazepine TOXICITY
Toxic dose : Over 10 mg/kg
Toxic serum or urine levels: Over 12 mg/L
Management: Treatment of mild to moderate toxicity is largely supportive. Sinus tachycardia should be treated with fluid resuscitation and benzodiazepines for anticholinergic symptoms. Dystonic ... |
Poisoning cause: Severe Carbamazepine TOXICITY
Toxic dose : Over 10 mg/kg
Toxic serum or urine levels: Over 40 mg/L
Management: Supportive care is the mainstay of treatment. Specific interventions based on the system of toxicity are as follows:
a) CNS: Mental status depression may require airway protection. Coma shoul... |
Poisoning cause: MILD TO MODERATE Theophylline TOXICITY
Toxic dose : Acute overdose of more than 50 mg/kg may result in serum levels above 100 mg/L and can include symptoms like vomiting, tremor, anxiety, and tachycardia.
Toxic serum or urine levels: Over 40 mcg/ml (chronic), 80 mcg/ml (acute)
Management: Establish ... |
Poisoning cause: SEVERE Theophylline TOXICITY
Toxic dose : Acute overdose of more than 50 mg/kg may result in serum levels above 100 mg/L and can include symptoms like vomiting, tremor, anxiety, and tachycardia.
Toxic serum or urine levels: Over 40 mcg/ml (chronic), 80 mcg/ml (acute)
Management: The primary effect o... |
Poisoning cause: CHRONIC Theophylline TOXICITY
Toxic serum or urine levels: Over 40 mcg/ml (chronic), 80 mcg/ml (acute)
Management: The primary effect of theophylline is increased sympathomimetic effects. The primary treatment is sedation with benzodiazepines (such as lorazepam 1 to 2 mg IV every 5 min titrated to effe... |
Poisoning cause: MILD TO MODERATE acute Lithium TOXICITY
Toxic dose : Ingestion of 1 mEq/kg (40 mg/kg) can produce a blood level of approximately 1.2 mEq/L.
Toxic serum or urine levels: Over 4 mEq/L (acute)
Management: Most acute lithium Overdoses may be safely managed with supportive care that includes: antiemetic... |
Poisoning cause: MILD TO MODERATE chronic Lithium TOXICITY
Toxic serum or urine levels: Between 1.5 and 2.5 mEq/L(Chronic) (predicted outcome is mild effect),
Management: For chronic toxicity, address underlying causes of decreased renal clearance, including intravenous fluids for dehydration or discontinuing medicati... |
Poisoning cause: SEVERE chronic Lithium TOXICITY
Toxic serum or urine levels:
Between 2.5 and 3.5 mEq/L (Chronic) (predicted outcome is moderate to severe effect),
Over 3.5 mEq/L (Chronic) (predicted outcome is severe effect).
Management: Orotracheal intubation for airway protection should be performed if recurrent se... |
Poisoning cause: Mild to Moderate Lead Toxicity
Toxic serum or urine levels: Over 5 mcg /dL
Management: The primary concerns of mild to moderate toxicity from lead exposure in young children are neurodevelopmental, specifically lower intelligence quotient scores and behavioral problems. Population studies suggest that ... |
Poisoning cause: Severe Lead Toxicity
Toxic serum or urine levels: Over 40 mcg /dL, usually needs chelator treatment).Blood lead levels of 60–80 mcg/dL may cause gastrointestinal symptoms and subclinical renal effects, while levels above 80 mcg/dL can lead to serious overt intoxication, including abdominal pain and nep... |
Poisoning cause: Mild to Moderate Acute Digoxin Toxicity
Toxic dose : Over 3 mg (adult and acute), Over 1 mg (children)
Toxic serum or urine levels: 10 ng/mL (acute)
Management: Patients who do not develop significant cardiac toxicity require only supportive care and monitoring. Patients with mild bradycardia and nons... |
Poisoning cause: Mild to Moderate Chronic Digoxin Toxicity
Toxic dose : Over 0.1 mg/kg (children)
Toxic serum or urine levels: Over 2 ng/mL (acute on chronic or chronic)
Management: Patients who do not develop significant cardiac toxicity require only supportive care and monitoring. Patients with mild bradycardia and n... |
Poisoning cause: Severe Acute Digoxin Toxicity
Toxic dose : Over 3 mg (adult and acute), Over 1 mg (children).Serum potassium levels higher than 5.5 mEq/L suggest severe poisoning.
Toxic serum or urine levels: 10 ng/mL (acute)
Management: Following acute ingestion, patients with hyperkalemia (greater than 5 mEq/L), ... |
Poisoning cause: Severe Chronic Digoxin Toxicity
Toxic dose : Over 0.1 mg/kg (children)
Toxic serum or urine levels: Over 2 ng/mL (acute on chronic or chronic)
Management: Following acute ingestion, patients with hyperkalemia (greater than 5 mEq/L), symptomatic bradycardia, ventricular ectopy, or dysrhythmias should be... |
Poisoning cause: Mild to Moderate Phenytoin Toxicity
Toxic dose : Over 20 mg/kg
Toxic serum or urine levels: Over 20 to 50 µg/mL (mild to moderate), Nystagmus is common at serum concentrations above 20 mg/L, ataxia, slurred speech, and tremor above 30 mg/L.
Management: For mild and moderate toxicity, treat with support... |
Poisoning cause: Severe Phenytoin Toxicity
Toxic dose : Over 20 mg/kg
Toxic serum or urine levels: Over 50 µg/mL (severe).lethargy, confusion, and stupor ensue with levels higher than 40 mg/L.
Management: For large phenytoin Overdoses, treat with supportive care, which may include intubation for comatose patients. If... |
Poisoning cause: Severe Methanol toxicity
Toxic dose : The minimum toxic dose of methanol is approximately 100 mg/kg
Toxic serum or urine levels: Over 40 mg/dL
Management: Patients presenting with severe acidosis, signs or symptoms of visual changes, or depressed level of consciousness should be started immediately ... |
Poisoning cause: Mild Methanol Toxicity
Toxic dose : The minimum toxic dose of methanol is approximately 100 mg/kg
Toxic serum or urine levels: Over 25 mg/dL
Management: Obtain a methanol level, serum chemistry, and a serum pH. A thorough visual exam should be performed, including visual acuity. An elevated osmolar g... |
Poisoning cause: Moderate Methanol toxicity
Toxic dose : The minimum toxic dose of methanol is approximately 100 mg/kg
Toxic serum or urine levels: Over 40 mg/dL
Management: Obtain a methanol level, serum chemistry, and a serum pH. A thorough visual exam should be performed, including visual acuity. An elevated osmol... |
Poisoning cause: Mild Acute Acetaminophen Toxicity
Toxic dose : Over 200 mg/kg (acute), 150 mg/kg (acute on chronic)
Toxic serum or urine levels: For evaluating acetaminophen level (APAP LEVEL, Tylenol level): consider the reported APAP level in the note and time post ingestion as ” time”and use this formula to calcula... |
Poisoning cause: Moderate Acute Acetaminophen Toxicity
Toxic dose : Over 200 mg/kg (acute), 150 mg/kg (acute on chronic)
Toxic serum or urine levels: For evaluating acetaminophen level (APAP LEVEL, Tylenol level): consider the reported APAP level in the note and time post ingestion as ” time”and use this formula to cal... |
Poisoning cause: Severe Acute Acetaminophen Toxicity
Toxic dose : Over 200 mg/kg (acute), 150 mg/kg (acute on chronic)
Toxic serum or urine levels: For evaluating acetaminophen level (APAP LEVEL, Tylenol level): consider the reported APAP level in the note and time post ingestion as ” time”and use this formula to calcu... |
Poisoning cause: Mild to Moderate Acetaminophen-Repeated Supratherapeutic Toxicity
Management: 1) Stop acetaminophen therapy. The vast majority of repeated supratherapeutic ingestions of acetaminophen can be managed with symptomatic and supportive care. Treatment should be initiated with n-acetylcysteine (NAC) if the p... |
Poisoning cause: Severe Acetaminophen-Repeated Supratherapeutic Toxicity
Management: Aggressive symptomatic and supportive care in addition to n-acetylcysteine therapy must be undertaken in severe toxicity. Intubate patients with respiratory compromise or encephalopathy. Maintain blood pressure with IV fluids and pres... |
Poisoning cause: Mild to Moderate Oral/Parenteral Toothpaste or Fluoride Exposure
Toxic dose : Over 3-5 mg/kg.Vomiting and abdominal pain are common with ingestions of 3 to 5 mg/kg of elemental fluoride. Hypocalcemia and muscular symptoms may appear with 5 to 10 mg/kg.
Management: Most patients with dermal exposure w... |
Poisoning cause: Severe Ocular Toothpaste or Fluoride Exposure
Management: Patients with ophthalmic exposure should have each eye irrigated with 1 L of normal saline, LR or water.
Clinical effect 1: Burns
Clinical effect 2: Conjunctival ischemia
Clinical effect 3: Chemosis |
Poisoning cause: Mild to Moderate Dermal Toothpaste or Fluoride Exposure
Management: Patients should be treated in a stepwise manner based on their response to therapy. The initial treatment for pain from dermal exposure is topical calcium. One method for making a gel is to mix calcium gluconate with methylcellulose or... |
Poisoning cause: SYSTEMIC Fluoride POISONING
Toxic dose : Vomiting and abdominal pain are common with ingestions of 3 to 5 mg/kg of elemental fluoride. Hypocalcemia and muscular symptoms may appear with 5 to 10 mg/kg.
Management: Early administration of high doses of calcium salts and magnesium may be life-saving. Adm... |
Poisoning cause: MILD TO MODERATE Salicylate TOXICITY
Toxic dose : The acute ingestion of more than 150 mg/kg or 6.5 g of aspirin equivalent, whichever is less. For oil of wintergreen (98% methyl salicylate), greater than a lick or taste by children under 6 years of age or greater than 4 mL by patients 6 years of age a... |
Poisoning cause: Severe Acute Salicylate Toxicity
Toxic dose : The acute ingestion of greather than 150 mg/kg or 6.5 g of aspirin equivalent, whichever is less. For oil of wintergreen (98% methyl salicylate), greater than a lick or taste by children under 6 years of age or greater than 4 mL by patients 6 years of age ... |
Poisoning cause: Severe Chronic Salicylate Toxicity
Toxic dose : Ingestions of greater than 100 mg/kg/day Over 2 days may produce toxicity.
Toxic serum or urine levels: Over 30 mg/dL
Management: Patients with severe poisoning should be continued on urine alkalinization. Hemodialysis should be strongly considered. Rel... |
Poisoning cause: Mild to Moderate Doxylamine Toxicity
Toxic dose : Over 4 mg/kg in children. toxic range in adults: >75–125 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation... |
Poisoning cause: Severe Doxylamine Toxicity
Toxic dose : Over 4 mg/kg in children. toxic range in adults: >75–125 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal a... |
Poisoning cause: MILD TO MODERATE Chlorpheniramine TOXICITY
Toxic dose : 6 months - 23 months: >0.5 mg/kg,
2 years - 5 years: >4 mg,
6 years - 11 years: >12 mg,
12 years - 79 years: >24 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shor... |
Poisoning cause: SEVERE Chlorpheniramine TOXICITY
Toxic dose : 6 months - 23 months: >0.5 mg/kg,
2 years - 5 years: >4 mg,
6 years - 11 years: >12 mg,
12 years - 79 years: >40 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents... |
Poisoning cause: MILD TO MODERATE Diphenhydramine TOXICITY
Toxic dose : Over 7.5 mg/kg in children. toxic range in adults:> 75–250 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for ag... |
Poisoning cause: SEVERE Diphenhydramine TOXICITY
Toxic dose : Over 7.5 mg/kg in children. toxic range in adults:> 75–250 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated cha... |
Poisoning cause: MILD TO MODERATE Hydroxyzine( Vistaril) TOXICITY
Toxic dose : In children:Over 7.5 mg/kg.Given that the usual single adult dose of hydroxyzine is listed as 25–50 mg, the toxic dose could be estimated as ranging from 75 mg (3 times the lower end of the usual dose) to 250 mg (5 times the higher end of th... |
Poisoning cause: SEVERE HHydroxyzine( Vistaril) TOXICITY
Toxic dose : In children:Over 7.5 mg/kg.Given that the usual single adult dose of hydroxyzine is listed as 25–50 mg, the toxic dose could be estimated as ranging from 75 mg (3 times the lower end of the usual dose) to 250 mg (5 times the higher end of the usual ... |
Poisoning cause: MILD TO MODERATE Cetirizine TOXICITY
Toxic dose : 6 months - 79 years doses more than >6 mg/kg OR >150 mg.
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation ... |
Poisoning cause: SEVERE Cetirizine TOXICITY
Toxic dose : 6 months - 79 years doses more than >6 mg/kg OR >150 mg.
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as ... |
Poisoning cause: MILD TO MODERATE Levocetirizine TOXICITY
Toxic dose : Over 300 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. Tachycardia is generally mild... |
Poisoning cause: SEVERE Levocetirizine TOXICITY
Toxic dose : Over 300 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as well. GI decontamination should be perform... |
Poisoning cause: MILD TO MODERATE Fexofenadine TOXICITY
Toxic dose : Over 300 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. Tachycardia is generally mild a... |
Poisoning cause: SEVERE Fexofenadine TOXICITY
Toxic dose : Over 300 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as well. GI decontamination should be performed... |
Poisoning cause: MILD TO MODERATE Desloratadine TOXICITY
Toxic dose : Over 300 mg
Management: Somnolence, anticholinergic effects (ie, mydriasis, flushing, fever, dry mouth, and decreased bowel sounds), tachycardia, mild hypertension, and nausea and vomiting are common after Overdose. Agitation, confusion, and hallucin... |
Poisoning cause: SEVERE Desloratadine TOXICITY
Toxic dose : Over 300 mg
Management: Severe effects may include agitated delirium, psychosis, seizures, coma, hypotension, QRS widening, and ventricular dysrhythmias, including torsade de pointe but are generally only reported in adults after very large, deliberate ingesti... |
Poisoning cause: MILD TO MODERATE Loratadine TOXICITY
Toxic dose : Over 300 mg
Management: The majority of antihistamine Overdoses requires only supportive care; give activated charcoal if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. Tachycardia is generally mild and... |
Poisoning cause: SEVERE Loratadine TOXICITY
Toxic dose : Over 300 mg
Management: Orotracheal intubation for airway protection should be performed early. Gastric lavage may be of benefit, if the patient presents soon after a large ingestion; administer activated charcoal as well. GI decontamination should be performed o... |
Poisoning cause: Mild to Moderate Captopril Toxicity
Toxic dose : Over 100 mg (child)
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids
Clinical effect 1: Hypotension |
Poisoning cause: Severe Captopril Toxicity
Toxic dose : Over 100 mg (child)
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, s... |
Poisoning cause: Mild to Moderate Enalapril Toxicity
Toxic dose : Over 30 mg (child)
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids.
Clinical effect 1: Hypotension |
Poisoning cause: Severe Enalapril Toxicity
Toxic dose : Over 30 mg (child)
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, so... |
Poisoning cause: Mild to Moderate Fosinopril Toxicity
Toxic dose : Over 30 mg (child)
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids.
Clinical effect 1: Hypotension |
Poisoning cause: Severe Fosinopril Toxicity
Toxic dose : Over 30 mg (child)
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, s... |
Poisoning cause: Mild to Moderate Lisinopril Toxicity
Toxic dose : Age Group: 6 months to 7 years: Greater than 4 mg/kg of body weight OR a total dose exceeding 40 mg of Lisinopril.
Age Group: 8 years to 18 years: Greater than 60 mg of Lisinopril.
Age Group: 19 years to 79 years: Greater than 80 mg of Lisinopril
Manage... |
Poisoning cause: Severe Lisinopril Toxicity
Toxic dose : Age Group: 6 months to 7 years: Greater than 4 mg/kg of body weight OR a total dose exceeding 40 mg of Lisinopril.
Age Group: 8 years to 18 years: Greater than 60 mg of Lisinopril.
Age Group: 19 years to 79 years: Greater than 80 mg of Lisinopril
Management: Adeq... |
Poisoning cause: Mild to Moderate Ramipril Toxicity
Toxic dose : Over 5 mg
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids.
Clinical effect 1: Hypotension |
Poisoning cause: Severe Ramipril Toxicity
Toxic dose : Over 5 mg
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium bicar... |
Poisoning cause: Mild to Moderate Trandolapril Toxicity
Toxic dose : Over 4 mg
Management: Most patients will have no symptoms, but patients with mild orthostatic hypotension can be treated by remaining prone. Those who remain hypotensive can be treated with IV fluids
Clinical effect 1: Hypotension |
Poisoning cause: Severe Trandolapril Toxicity
Toxic dose : Over 4 mg
Management: Adequate circulatory support with IV fluids and vasopressors (if needed) should be assured if the patient presents with circulatory collapse. Correct severe hyperkalemia using standard treatments such as glucose, insulin, calcium, sodium b... |
Poisoning cause: Mild to Moderate Amoxicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Treatment is symptomatic and supportive. Treat significant vomiting and diarrhea with IV fluids; administer antiemetics, as needed. HYPERSENSITIVITY REACTION: Administer antihistamines, with or without inhaled beta agonists, ... |
Poisoning cause: Severe Oral Amoxicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Acute anaphylaxis is more likely to occur after parenteral exposure, but may develop with all routes. Administer oxygen, aggressive airway management, antihistamines, epinephrine, corticosteroids, ECG monitoring, and IV fluids. Dy... |
Poisoning cause: Mild to Moderate Ampicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Treatment is symptomatic and supportive. Treat significant vomiting and diarrhea with IV fluids; administer antiemetics, as needed. HYPERSENSITIVITY REACTION: Administer antihistamines, with or without inhaled beta agonists, c... |
Poisoning cause: Severe Ampicillin Toxicity
Toxic dose : Over 250 mg/kg
Management: Acute anaphylaxis is more likely to occur after parenteral exposure, but may develop with all routes. Administer oxygen, aggressive airway management, antihistamines, epinephrine, corticosteroids, ECG monitoring, and IV fluids. Dysrhyth... |
Poisoning cause: Mild to Moderate Ethylene Glycol Toxicity
Toxic dose : Over 10 cc, 2000 mg (adult), 10 mL (adult), 1 swallow (adult), 1 taste or lick (child)
Toxic serum or urine levels: Over 25 mg/dL
Management: Monitor serum electrolytes, renal function and ethylene glycol concentration. A peak ethylene glycol conce... |
Poisoning cause: Severe Ethylene Glycol Toxicity
Toxic dose : Over 10 cc, 2000 mg (adult), 10 mL (adult), 1 swallow (adult), 1 taste or lick (child)
Toxic serum or urine levels: Over 25 mg/dL
Management: CNS depression may require intubation; adequate minute ventilation must be insured to prevent abrupt worsening of ac... |
Poisoning cause: Mild to Moderate Benzocaine Toxicity
Toxic dose : Over 100 mg (child)
Management: Patients with mild to moderate toxicity can be treated with supportive care. Intravenous fluids should be given to maintain urine output and supplemental oxygen applied
Clinical effect 1: Methemoglobinemia
Clinical effect... |
Poisoning cause: Severe Benzocaine Toxicity
Toxic dose : Over 100 mg (child)
Management: Patients with evidence of end-organ ischemia should be treated with methylene blue regardless of the methemoglobin concentration. However, patients are unlikely to have end-organ ischemia with concentrations less than 20%. Treatmen... |
Poisoning cause: Mild to Moderate Aripiprazole Toxicity
Toxic dose : Over 15 mg (under 12 years old and acute), 50 mg (Over 12 years old and acute)
Management: For management of mild to moderate toxicity, good supportive care is all that is needed. Treatment may include fluids and antiemetics for patients with nausea a... |
Poisoning cause: Severe Aripiprazole Toxicity
Toxic dose : Over 15 mg (under 12 years old and acute), 50 mg (Over 12 years old and acute)
Management: Mainstay of treatment is good supportive care, including airway management for patients with severe CNS sedation and fluid and vasopressors for hypotension. For patients ... |
Poisoning cause: Mild to Moderate Ibuprofen Toxicity
Toxic dose : Over 200 mg/kg (mild to moderate)
Management: Most ibuprofen toxicity resolves with supportive care. Otherwise healthy patients with a history of ibuprofen poisoning generally require only supportive care and fluid and electrolyte replacement
Clinical ef... |
Poisoning cause: Severe Ibuprofen Toxicity
Toxic dose : Over 400 mg/kg
Management: Maintain an open airway and support ventilation. Treat seizures with benzodiazepines, hypotension with fluids and adrenergic vasopressors, and coma with intubation. Monitor ECG and arterial blood gases in patients with severe toxicity.
... |
Poisoning cause: Mild to Moderate Felodipine Toxicity
Toxic dose : Over 10 mg (adult), 0.3 mg/kg (child)
Management: Patients who have asymptomatic bradycardia can be admitted and observed with telemetry. Obtain peripheral intravenous access and monitor ECG. Mild hypotension may only require treatment with intravenous ... |
Poisoning cause: Severe Felodipine Toxicity
Toxic dose : Over 10 mg (adult), 0.3 mg/kg (child)
Management: Patients with bradycardia and hypotension require standard ACLS treatment. Place a central line and consider placement of an arterial line. Standard first line treatment includes atropine for bradycardia although ... |
Poisoning cause: Mild to Moderate Indomethacin Toxicity
Toxic dose : Over 175 mg (child), 1500 mg (adult)
Management: Treat GI distress and administer IV fluids. Manage mild hypotension with IV fluids.
Clinical effect 1: Nausea
Clinical effect 2: Vomiting
Clinical effect 3: Abdominal pain |
Poisoning cause: Severe Indomethacin Toxicity
Toxic dose : Over 175 mg (child), 1500 mg (adult)
Management: Administer IV fluids, treat GI distress and monitor for GI bleeding. Patients with severe altered mental status may require intubation. Treat seizures with IV benzodiazepines; barbiturates or propofol may be need... |
Poisoning cause: Mild to Moderate Sertraline Toxicity
Toxic dose : Over 250 mg.Based on Olson guidleine >500–2000 mg
Management: Primarily supportive care; activated charcoal may be helpful in patients presenting shortly after ingestion. Give benzodiazepines titrated to effect for anxiety and seizures.
Clinical effect... |
Poisoning cause: Severe Sertraline Toxicity
Management: Consider activated charcoal if patients present early after ingestion. If significant CNS depression occurs, intubate the patient for airway protection before giving charcoal. Consider intravenous lipid therapy early for patients with ventricular dysrhythmias or h... |
Poisoning cause: Mild to Moderate Celexa (Citalopram) Toxicity
Toxic dose : Over 5 mg/kg or 100 mg(child). Adults:over 400-800 mg
Management: Most patients require only supportive care. Control agitation and confusion with either benzodiazepines or serotonin antagonist such as cyproheptadine or chlorpromazine. Manage ... |
Poisoning cause: Severe Celexa (Citalopram) Toxicity
Toxic dose : Over 5 mg/kg or 100 mg(child). Adults:over 400-800 mg
Management: Early intubation, neuromuscular paralysis, ventilation assistance, and aggressive cooling should be performed if the patient presents with respiratory depression, severe muscle rigidity, ... |
Poisoning cause: MILD TO MODERATE Escitalopram (Lexapro) TOXICITY
Toxic dose : Over 50 mg
Management: Most patients require only supportive care. Control agitation and confusion with either benzodiazepines or serotonin antagonist such as cyproheptadine or chlorpromazine. Manage mild hypotension with IV fluids. Hyperten... |
Poisoning cause: SEVERE Escitalopram (Lexapro) TOXICITY
Toxic dose : Over 50 mg
Management: Early intubation, neuromuscular paralysis, ventilation assistance, and aggressive cooling should be performed if the patient presents with respiratory depression, severe muscle rigidity, and severe hyperthermia. Adequate circula... |
Poisoning cause: MILD TO MODERATE Fluoxetine TOXICITY
Toxic dose : based on most referencess toxic dose is Over 100 mg. However Per Olson guideline toxic dose in adults :over 200-800 mg
Management: Primarily supportive care; a single dose of activated charcoal may be helpful in patients presenting shortly after inge... |
Poisoning cause: MILD TO MODERATE Gabapentin TOXICITY
Toxic dose : Over 35000 mg based on some references and more than 18 mg/kg based on other references
Management: Treatment of gabapentin exposure is largely supportive with mild/moderate symptoms. An observation period of 4 to 6 hours is reasonable
Clinical effect 1... |
Poisoning cause: SEVERE Gabapentin TOXICITY
Toxic dose : Over 35000 mg based on some references and more than 18 mg/kg based on other references
Management: Treatment of gabapentin exposure is largely supportive in nature with careful attention to airway protection in severe cases. Hypotension is usually mild respondin... |
Poisoning cause: MILD TO MODERATE Loperamide (Imodium) TOXICITY
Toxic dose : Over 0.4 mg/kg (Infant and child Over 6 months old)
Management: Supportive care is the mainstay of treatment. Administer naloxone for CNS or respiratory depression.
Clinical effect 1: Drowsiness/lethargy
Clinical effect 2: Nausea
Clinical eff... |
Poisoning cause: SEVERE Loperamide (Imodium) TOXICITY
Toxic dose : Over 0.4 mg/kg (Infant and child Over 6 months old)
Management: Supportive care is the mainstay of treatment. Administer oxygen and monitor for respiratory and CNS depression. The AACT and AAPCC loperamide position statement endorsed by the ACMT, recomm... |
Poisoning cause: MILD TO MODERATE acute L-thyroxine TOXICITY
Toxic dose : Over 0.5-2 mg (child). Adult:6 months - 79 years ≥2 mg
Management: Primarily supportive care; single dose activated charcoal is advised in patients presenting shortly after an ingestion of more than 3 mg.
Clinical effect 1: Subtle tremor
Clinica... |
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